Daniel W. Bellott, Jennifer F. Hughes, Helen Skaletsky, Laura G. Brown, Tatyana Pyntikova,
Ting-Jan Cho, Natalia Koutseva, Sara Zaghlul, Tina Graves, Susie Rock, Colin Kremitzki,
Robert S. Fulton, Shannon Dugan, Yan Ding, Donna Morton, Ziad Khan, Lora Lewis,
Christian Buhay, Qiaoyan Wang, Jennifer Watt, Michael Holder, Sandy Lee, Lynne Nazareth,
Jessica Alfoldi, Steve Rozen, Donna M. Muzny, Wesley C. Warren, Richard A. Gibbs,
Richard K. Wilson & David C. Page
Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators.
All Figures and Tables are identical to those provided to the journal.
- Extended Data Table 1. PANTHER statistical overrepresentation results.
- Extended Data Table 2. Accession numbers of mouse pseudoautosomal region genes.
- Extended Data Table 3. Patients with structurally varuant X and Y Chromosomes.
- Source Data Figure 1. Status of ancestral genes in each lineage
- Source Data Figure 4. Constraints on dynamics of Y-chromosome gene content
- Source Data Figure 5. Includes:
- 5a Branch lengths for multi-copy and single-copy X-Y pair genes
- 5b Human haploinsufficiency scores for ancestral genes
- 5c Calculated expression breadth for ancestral genes
- 5d Ensembl human-mouse dN/dS for ancestral genes
- Supplementary Tables. (XLS) Includes:
- 1: BAC clone accession numbers, and nucleotide positions in MSY sequence assemblies
- 2: Ancestral genes
- 3: Accession numbers of genes in this study
- 4: PANTHER statistical overrepresentation results
- 5: Values of dN, dS, and dN/dS for all X-Y pairs
- Supplementary Notes. (PDF) Include:
- 1: SHIMS strategy and error estimates
- 2: PANTHER Statistical Overrepresentation Test
- 3: Identification and recalibration of evolutionary strata
- 4: Modeling kinetics of Y-chromosome decay
- 5: Haplolethality of broadly expressed, dosage-sensitive X-Y pair genes